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The field or Radiation Biology has seen in the last fifty years dramatic developments in its focus and a continuous movement forward internationally. Research topics and discoveries once thought to represent the interests of a highly specialized group of scientists are now main stream and attract an ever increasing number of researchers and clinicians active in areas as diverse as immunology, cancer,...
With the discovery of X-rays by Roentgen in 1895 came the birth of radiation research, a multidisciplinary field that has since seen remarkable progress. Over the past century our field has witnessed major advancements in the measurement of radiation fields, the identification of critical radiogenic lesions in cells, the use of therapeutic irradiation regimes to treat cancer patients, and the control...
Low dose radio therapy (LD-RT) has been used since the early 30’s of the past century for the amelioration of inflammatory processes, e.g. abscesses or arthritidies. The mechanism of action, however, remained completely unclear. We have shown in vitro that LD-RT in the dose range between 0.3 and 0.7 Gy inhibits adhesion of lymphocytes to endothelial cells by discontinuous induction of apoptosis and...
The genetically determined balance of genomic stability and variation has been very important in evolution. The maintenance of this balance is essential for human health; disturbances give multiple causes for disease. In the past, radiobiological research contributed significantly to the elucidation of the mechanisms for genomic stability. Future research will continue to identify genes and polymorphisms...
In recent years, we have accumulated a wealth of information concerning DNA damage induced by ionising radiation. It can be expected that the biochemistry of DNA repair pathways and the proteins involved will soon be elucidated in their entirety. In contrast, our knowledge on the impact of topology on the biological consequences of irradiation is still scarce. This is somewhat unexpected, as the importance...
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